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Cigarette smoking promotes acid reflux through multiple mechanisms including reduced lower esophageal sphincter pressure, increased transient sphincter relaxations, impaired esophageal clearance, and decreased saliva production

Thus smoking primarily eats into the relatively healthy middle years rather than shortening the period at the end of life, which is often marked by chronic illness or disability

This corneal abrasion appears as a yellow-green area when stained with fluorescein and viewed with a blue light

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These results aligned with the high deacetylation effect observed in the various TA pretreatments